PREPARATION AND ANTIFUNGAL PROPERTIES OF “ARGODERYL” LINIMENT BASED ON CARBOXYMETHYLCELLULOSE AND SILVER NANOPARTICLES

Orginal langulage: Uzbek

Abstract

Silver nanoparticles (AgNP) stabilized in polymeric hydrogels from sodium carboxymethylcellulose (Na-CMC) have been synthesized, their structure, physicochemical properties, and bactericidal activity have been studied. Using transmission electron microscopy, the shape, concentration, and size of AgNP included in the Na-CMC hydrogel structure were established. Studies have shown that spherical silver nanoparticles in the Na-CMC hydrogel structure with a size of 2−45 nm have a high bactericidal activity. These studies have shown that changes in the size and shape of AgNP affect the biological activity in fungal diseases. On the basis of Na-CMC hydrogel containing AgNP, castor oil, menthol, propylene glycol and sorbic acid, “Argoderil” liniment was developed for the prevention and treatment of fungal diseases.